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The Emperor’s New Probes

April 10, 2019

Ubiquitin (Ub) is ubiquitous.  This small, 76-residue protein is used to mark cellular proteins for degradation by the ubiquitin proteasome system (UPS).  Two key enzyme families, Ub ligases and deubiquitylation enzymes (DUBs), are responsible for putting on and taking off … Read more

AMPs Making Noise as Antimalarials

January 4, 2019

This week, the lab has been reading about peptide therapeutics for malaria. Malaria is yet another infectious disease seeing a sharp rise in multi-drug resistant cases in recent years. Artemisinin and artemisinin combination therapies (ACTs) are the “go-to” treatment options … Read more