Re-Arming Arylomycins
November 30, 2018
Recently we delved into the literature on new and improved arylomycin antibiotics, in particular, this recent report in Nature by researchers at Genentech. Arylomycins are a class of macrocyclic peptides known to inhibit the bacterial type I signal peptidase pathway … Read more
Thinking About Piperazic Acid-Containing Natural Products
June 8, 2018
We’ve been reading the recent work of the Del Valle lab at USF and reflecting on the intriguing chemistry of what they call N-amino peptides (NAPs). The unique structural and electronic features of NAPs make them potentially useful as peptidomimetics … Read more