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Re-Arming Arylomycins

November 30, 2018

Recently we delved into the literature on new and improved arylomycin antibiotics, in particular, this recent report in Nature by researchers at Genentech. Arylomycins are a class of macrocyclic peptides known to inhibit the bacterial type I signal peptidase pathway … Read more

Thinking About Piperazic Acid-Containing Natural Products

June 8, 2018

We’ve been reading the recent work of the Del Valle lab at USF and reflecting on the intriguing chemistry of what they call N-amino peptides (NAPs).  The unique structural and electronic features of NAPs make them potentially useful as peptidomimetics … Read more